MFN1

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
Full Name
mitofusin 1
Function
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303).

Membrane clustering requires GTPase activity (PubMed:27920125).

It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303).

Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376).

Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376).

Has low GTPase activity (PubMed:27920125, PubMed:28114303).
Biological Process
GTP metabolic process Source: UniProtKB
Mitochondrial fusion Source: BHF-UCL
Mitochondrial membrane fusion Source: UniProtKB
Mitochondrion localization Source: UniProtKB
Positive regulation of mitochondrial membrane potential Source: Ensembl
Cellular Location
Mitochondrion outer membrane
Isoform 2:
Cytoplasm
Topology
Cytoplasmic: 1-584
Helical: 585-605
Mitochondrial intermembrane: 606-608
Helical: 609-629
Cytoplasmic: 630-741
PTM
Ubiquitinated by non-degradative ubiquitin by PRKN (PubMed:23933751). Deubiquitination by USP30 inhibits mitochondrial fusion (By similarity). Ubiquitinated by MARCHF5 (PubMed:20103533). When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN (PubMed:23933751).
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Anti-MFN1 antibodies

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Mouse Anti-MFN1 Monoclonal Antibody (11E91H12) (CBMAB-1395-YC)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Rat
Clone: 11E91H12
Application*: IC, IF, WB
Datasheet SDS

Rabbit Anti-MFN1 Recombinant Antibody (
11G8) (V2LY-0725-LY1261)

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Target: MFN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11G8
Application*: E, F
Datasheet SDS

Mouse Anti-MFN1 Recombinant Antibody (3H3) (CBMAB-BR350LY)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG2B
Specificity: Human
Clone: 3H3
Application*: IF, ICC, WB
Datasheet SDS

Rabbit Anti-MFN1 Recombinant Antibody (D6E2S) (CBMAB-CP1541-LY)

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Target: MFN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6E2S
Application*: WB, IP, IF (IC)
Datasheet SDS

Mouse Anti-MFN1 (AA 1-742) Recombinant Antibody (CBFYM-2156) (CBMAB-M2338-FY)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2156
Application*: E, WB
Datasheet SDS

Mouse Anti-MFN1 Recombinant Antibody (CBFYM-2155) (CBMAB-M2337-FY)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2155
Application*: P, WB
Datasheet SDS

Mouse Anti-MFN1 (AA 209-469) Recombinant Antibody (CBFYM-2154) (CBMAB-M2336-FY)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2154
Application*: WB
Datasheet SDS

Mouse Anti-MFN1 Recombinant Antibody (CBFYM-0630) (CBMAB-M0765-FY)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0630
Application*: E, WB
Datasheet SDS

Mouse Anti-MFN1 Recombinant Antibody (CBFYM-0033) (CBMAB-M0038-FY)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: CBFYM-0033
Application*: WB, IF
Datasheet SDS

Rabbit Anti-MFN1 Recombinant Antibody (BA0344) (CBMAB-0498CQ)

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Target: MFN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0344
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-MFN1 Recombinant Antibody (BA0409) (CBMAB-0497CQ)

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Target: MFN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Monkey
Clone: BA0409
Application*: F, IF, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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