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MNX1

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

MOTOR NEURON AND PANCREAS HOMEOBOX 1

Function

Putative transcription factor involved in pancreas development and function.

Biological Process

Central nervous system development Source: GO_Central
Endocrine pancreas development Source: GO_Central
Neuron projection morphogenesis Source: GO_Central
Spinal cord motor neuron cell fate specification Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Currarino syndrome (CURRAS):
The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

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Anti-MNX1 antibodies

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Mouse Anti-MNX1 Recombinant Antibody (CBFYH-2654) (CBMAB-H3698-FY)

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Target: MNX1

Host: Mouse

Specificity: Human

Clone: CBFYH-2654

Application*: WB, IP, IF, E

Rabbit Anti-MNX1 (C-terminus) Recombinant Antibody (CBFYM-2444) (CBMAB-M2631-FY)

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Target: MNX1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Human

Clone: CBFYM-2444

Application*: WB, IP, P

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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