MNX1

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

MOTOR NEURON AND PANCREAS HOMEOBOX 1

Function

Putative transcription factor involved in pancreas development and function.

Biological Process

Central nervous system development Source: GO_Central
Endocrine pancreas development Source: GO_Central
Neuron projection morphogenesis Source: GO_Central
Spinal cord motor neuron cell fate specification Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Currarino syndrome (CURRAS):
The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

Anti-MNX1 antibodies

Mouse Anti-MNX1 Recombinant Antibody (CBFYH-2654) (CBMAB-H3698-FY)

Datasheet

SDS

Target: MNX1

Host: Mouse

Specificity: Human

Clone: CBFYH-2654

Application*: WB, IP, IF, E

Rabbit Anti-MNX1 (C-terminus) Recombinant Antibody (CBFYM-2444) (CBMAB-M2631-FY)

Datasheet

SDS

Target: MNX1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Human

Clone: CBFYM-2444

Application*: WB, IP, P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)