Rabbit Anti-MNX1 (C-terminus) Recombinant Antibody (CBFYM-2444) (CBMAB-M2631-FY)

This product is rabbit antibody that recognizes MNX1. The antibody CBFYM-2444 can be used for immunoassay techniques such as: WB, IP, IHC-P.
See all MNX1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Mouse, Human

Clone

CBFYM-2444

Antibody Isotype

IgG

Application

WB, IP, IHC-P

Basic Information

Immunogen

A synthetic peptide corresponding to residues near the C-terminus of human HB9

Specificity

Mouse, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.05% BSA, 50% glycerol

Preservative

0.01% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

C-terminus

Target

Full Name

MOTOR NEURON AND PANCREAS HOMEOBOX 1

Introduction

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	3110
Mouse	15285

UniProt ID

Human	P50219
Mouse	Q9QZW9

Alternative Names

Motor Neuron And Pancreas Homeobox 1; Homeobox Protein HB9; Homeobox HB9; HLXB9; Motor Neuron And Pancreas Homeobox Protein 1; Homeo Box HB9; HOXHB9; SCRA1; HB9

Function

Putative transcription factor involved in pancreas development and function.

Biological Process

Central nervous system development Source: GO_Central
Endocrine pancreas development Source: GO_Central
Neuron projection morphogenesis Source: GO_Central
Spinal cord motor neuron cell fate specification Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Currarino syndrome (CURRAS):
The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

References

Wu, J., Yue, C., Xu, W., Li, H., Zhu, J., & Li, L. (2023). MNX1 facilitates the malignant progress of lung adenocarcinoma through transcriptionally upregulating CCDC34. Oncology Letters, 26(2), 1-12.

Aly, H. H., De Franco, E., Flanagan, S. E., & Elhenawy, Y. I. (2023). MNX1 mutations causing neonatal diabetes: Review of the literature and report of a case with extra‐pancreatic congenital defects presenting in severe diabetic ketoacidosis. Journal of Diabetes Investigation, 14(4), 516-521.

Sun, M. A., Ralls, S., Wu, W., Demmerle, J., Jiang, J., Miller, C., ... & Macfarlan, T. S. (2021). Homeobox transcription factor MNX1 is crucial for restraining the expression of pan-neuronal genes in motor neurons. bioRxiv, 2021-08.

Xiao, L., Hong, L., & Zheng, W. (2019). Motor neuron and pancreas homeobox 1 (MNX1) is involved in promoting squamous cervical cancer proliferation via regulating cyclin E. Medical science monitor: international medical journal of experimental and clinical research, 25, 6304.

Schwaller, J. (2019). Novel insights into the role of aberrantly expressed MNX1 (HLXB9) in infant acute myeloid leukemia. haematologica, 104(1), 1.

Yang, R., Wang, L., & Han, M. (2019). MNX1‐AS1 is a novel biomarker for predicting clinical progression and poor prognosis in lung adenocarcinoma. Journal of cellular biochemistry, 120(5), 7222-7228.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-MNX1 Recombinant Antibody (CBFYH-2654)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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