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MOB1B

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.

Full Name

MOB KINASE ACTIVATOR 1B

Function

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Biological Process

Hippo signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of protein autophosphorylation Source: UniProtKB
Signal transduction Source: GO_Central

Cellular Location

Nucleus
Cytoplasm

PTM

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.

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Anti-MOB1B antibodies

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Mouse Anti-MOB1B Recombinant Antibody (2F8) (CBMAB-A5541-LY)

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Target: MOB1B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2F8

Application*: IF, E

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-2453) (CBMAB-M2640-FY)

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Target: MOB1B

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-2453

Application*: IH, WB

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-2452) (CBMAB-M2639-FY)

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Target: MOB1B

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-2452

Application*: IC, IF

Mouse Anti-MOB1B (AA 120-216) Recombinant Antibody (CBFYM-2451) (CBMAB-M2638-FY)

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Target: MOB1B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2451

Application*: E, IF

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-2449) (CBMAB-M2636-FY)

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Target: MOB1B

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-2449

Application*: F, WB

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-0703) (CBMAB-M0839-FY)

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Target: MOB1B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0703

Application*: E

More Infomation

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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