MOB1B

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.
Full Name
MOB KINASE ACTIVATOR 1B
Function
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Biological Process
Hippo signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of protein autophosphorylation Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
PTM
Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
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Anti-MOB1B antibodies

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Mouse Anti-MOB1B Recombinant Antibody (2F8) (CBMAB-A5541-LY)

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Target: MOB1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F8
Application*: IF, E
Datasheet SDS

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-2453) (CBMAB-M2640-FY)

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Target: MOB1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2453
Application*: IH, WB
Datasheet SDS

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-2452) (CBMAB-M2639-FY)

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Target: MOB1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2452
Application*: IC, IF
Datasheet SDS

Mouse Anti-MOB1B (AA 120-216) Recombinant Antibody (CBFYM-2451) (CBMAB-M2638-FY)

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Target: MOB1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2451
Application*: E, IF
Datasheet SDS

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-2449) (CBMAB-M2636-FY)

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Target: MOB1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2449
Application*: F, WB
Datasheet SDS

Mouse Anti-MOB1B Recombinant Antibody (CBFYM-0703) (CBMAB-M0839-FY)

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Target: MOB1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0703
Application*: E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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