MTNR1A

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
Full Name
Melatonin Receptor 1A
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian rhythm Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Mating behavior Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-63
Helical: 64-84
Extracellular: 85-102
Helical: 103-123
Cytoplasmic: 124-142
Helical: 143-163
Extracellular: 164-187
Helical: 188-208
Cytoplasmic: 209-240
Helical: 241-261
Extracellular: 262-274
Helical: 275-295
Cytoplasmic: 296-350
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Anti-MTNR1A antibodies

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Mouse Anti-MTNR1A Recombinant Antibody (A1201) (CBMAB-AP4494LY)

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Target: MTNR1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1201
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-MTNR1A Recombinant Antibody (CBFYM-2759) (CBMAB-M2952-FY)

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Target: MTNR1A
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYM-2759
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-MTNR1A (AA 319-333) Recombinant Antibody (CBFYM-2758) (CBMAB-M2951-FY)

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Target: MTNR1A
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Pig, Rabbit, Rat
Clone: CBFYM-2758
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-MTNR1A Recombinant Antibody (CBFYM-2757) (CBMAB-M2950-FY)

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Target: MTNR1A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2757
Application*: WB, IC, P, C, E, IP, IF, F
Datasheet SDS

Mouse Anti-MTNR1A Recombinant Antibody (CBFYM-2756) (CBMAB-M2949-FY)

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Target: MTNR1A
Host: Mouse
Specificity: Horse, Human, Mouse, Rabbit, Rat
Clone: CBFYM-2756
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-MTNR1A (AA 216-257) Recombinant Antibody (CBFYM-2755) (CBMAB-M2948-FY)

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Target: MTNR1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: CBFYM-2755
Application*: E, WB
Datasheet SDS

Mouse Anti-MTNR1A Recombinant Antibody (CBFYM-2754) (CBMAB-M2947-FY)

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Target: MTNR1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: CBFYM-2754
Application*: WB, IC, C, P, E
Datasheet SDS

Mouse Anti-MTNR1A (AA 216-257) Recombinant Antibody (CBFYM-0523) (CBMAB-M0651-FY)

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Target: MTNR1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: CBFYM-0523
Application*: E, IC, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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