MTNR1A

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Melatonin Receptor 1A

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian rhythm Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Mating behavior Source: ProtInc

Cell membrane

Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-63
Helical: 64-84
Extracellular: 85-102
Helical: 103-123
Cytoplasmic: 124-142
Helical: 143-163
Extracellular: 164-187
Helical: 188-208
Cytoplasmic: 209-240
Helical: 241-261
Extracellular: 262-274
Helical: 275-295
Cytoplasmic: 296-350