Mouse Mtnr1a ELISA Kit (V2LY-0626-LY2627)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0016 ng/mL
Detection Range
0.003-0.9 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
39.8 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Melatonin Receptor 1A
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian rhythm Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Mating behavior Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-63
Helical: 64-84
Extracellular: 85-102
Helical: 103-123
Cytoplasmic: 124-142
Helical: 143-163
Extracellular: 164-187
Helical: 188-208
Cytoplasmic: 209-240
Helical: 241-261
Extracellular: 262-274
Helical: 275-295
Cytoplasmic: 296-350

Antonopoulou, D., Giantsis, I. A., Symeon, G. K., & Avdi, M. (2023). Association of MTNR1A and GDF9 gene allelles with the reproductive performance, response to oestrus induction treatments and prolificacy, in improved and non‐improved local indigenous sheep breeds. Reproduction in Domestic Animals, 58(11), 1532-1541.

Kolomeichuk, S. N., Korneva, V. A., Kuznetsova, T. Y., Korostovtseva, L. S., Bochkarev, M. V., Sviryaev, Y. V., & Blagonravov, M. L. (2023). MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension. Bulletin of Experimental Biology and Medicine, 174(4), 460-463.

Arjoune, A., Alsaleh, A. B., Messaoudi, S. A., Chelbi, H., Jelassi, R., Assidi, M., ... & Sirard, M. A. (2023). Analysis of MTNR1A genetic polymorphisms and their association with the reproductive performance parameters in two Mediterranean sheep breeds. Animals, 13(3), 448.

Yang, D., He, Y., Yuan, L., Ge, W., Chen, S., Chen, W., ... & Bao, Y. (2022). Expression and distribution of MTNR1A in the hypothalamus-pituitary-gonadal axis of Tibetan sheep during the estrous cycle. Gene, 839, 146731.

Pulinas, L., Starič, J., Cosso, G., Curone, G., Mura, M. C., Carcangiu, V., & Luridiana, S. (2022). MTNR1A gene polymorphisms and reproductive recovery after seasonal anoestrus in different Mediterranean sheep breeds. Animal Reproduction Science, 236, 106905.

Cosso, G., Nehme, M., Luridiana, S., Pulinas, L., Curone, G., Hosri, C., ... & Mura, M. C. (2021). Detection of polymorphisms in the mtnr1a gene and their association with reproductive performance in Awassi ewes. Animals, 11(2), 583.

Luridiana, S., Cosso, G., Pulinas, L., Di Stefano, M. V., Curone, G., Carcangiu, V., & Mura, M. C. (2020). New polymorphisms at MTNR1A gene and their association with reproductive resumption in sarda breed sheep. Theriogenology, 158, 438-444.

Abecia, J. A., Mura, M. C., Carvajal-Serna, M., Pulinas, L., Macías, A., Casao, A., ... & Carcangiu, V. (2020). Polymorphisms of the melatonin receptor 1A (MTNR1A) gene influence the age at first mating in autumn-born ram-lambs and sexual activity of adult rams in spring. Theriogenology, 157, 42-47.

Starič, J., Farci, F., Luridiana, S., Mura, M. C., Pulinas, L., Cosso, G., & Carcangiu, V. (2020). Reproductive performance in three Slovenian sheep breeds with different alleles for the MTNR1A gene. Animal reproduction science, 216, 106352.

Mura, M. C., Luridiana, S., Pulinas, L., Di Stefano, M. V., & Carcangiu, V. (2019). Reproductive response to male joining with ewes with different allelic variants of the MTNR1A gene. Animal reproduction science, 200, 67-74.

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For research use only. Not intended for any clinical use.

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