Sign in or Register   Sign in or Register
  |  

Mouse Anti-MTNR1A Recombinant Antibody (CBFYM-2754) (CBMAB-M2947-FY)

This product is mouse antibody that recognizes MTNR1A. The antibody CBFYM-2754 can be used for immunoassay techniques such as: WB, ICC, IHC-Fr, IHC-P, ELISA.
See all MTNR1A antibodies

Summary

Host Animal
Mouse
Specificity
Cattle
Clone
CBFYM-2754
Antibody Isotype
IgG
Application
WB, ICC, IHC-Fr, IHC-P, ELISA

Basic Information

Immunogen
The antibody is a mouse monoclonal antibody raised against MTNR1A
Specificity
Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Melatonin Receptor 1A
Introduction
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Entrez Gene ID
539948
UniProt ID
O02769
Alternative Names
Melatonin Receptor 1A; Mel1a Receptor; MEL-1A-R; Melatonin Receptor Type 1A; MT1
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian rhythm Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Mating behavior Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-63
Helical: 64-84
Extracellular: 85-102
Helical: 103-123
Cytoplasmic: 124-142
Helical: 143-163
Extracellular: 164-187
Helical: 188-208
Cytoplasmic: 209-240
Helical: 241-261
Extracellular: 262-274
Helical: 275-295
Cytoplasmic: 296-350

Antonopoulou, D., Giantsis, I. A., Symeon, G. K., & Avdi, M. (2023). Association of MTNR1A and GDF9 gene allelles with the reproductive performance, response to oestrus induction treatments and prolificacy, in improved and non‐improved local indigenous sheep breeds. Reproduction in Domestic Animals, 58(11), 1532-1541.

Kolomeichuk, S. N., Korneva, V. A., Kuznetsova, T. Y., Korostovtseva, L. S., Bochkarev, M. V., Sviryaev, Y. V., & Blagonravov, M. L. (2023). MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension. Bulletin of Experimental Biology and Medicine, 174(4), 460-463.

Arjoune, A., Alsaleh, A. B., Messaoudi, S. A., Chelbi, H., Jelassi, R., Assidi, M., ... & Sirard, M. A. (2023). Analysis of MTNR1A genetic polymorphisms and their association with the reproductive performance parameters in two Mediterranean sheep breeds. Animals, 13(3), 448.

Yang, D., He, Y., Yuan, L., Ge, W., Chen, S., Chen, W., ... & Bao, Y. (2022). Expression and distribution of MTNR1A in the hypothalamus-pituitary-gonadal axis of Tibetan sheep during the estrous cycle. Gene, 839, 146731.

Pulinas, L., Starič, J., Cosso, G., Curone, G., Mura, M. C., Carcangiu, V., & Luridiana, S. (2022). MTNR1A gene polymorphisms and reproductive recovery after seasonal anoestrus in different Mediterranean sheep breeds. Animal Reproduction Science, 236, 106905.

Cosso, G., Nehme, M., Luridiana, S., Pulinas, L., Curone, G., Hosri, C., ... & Mura, M. C. (2021). Detection of polymorphisms in the mtnr1a gene and their association with reproductive performance in Awassi ewes. Animals, 11(2), 583.

Luridiana, S., Cosso, G., Pulinas, L., Di Stefano, M. V., Curone, G., Carcangiu, V., & Mura, M. C. (2020). New polymorphisms at MTNR1A gene and their association with reproductive resumption in sarda breed sheep. Theriogenology, 158, 438-444.

Abecia, J. A., Mura, M. C., Carvajal-Serna, M., Pulinas, L., Macías, A., Casao, A., ... & Carcangiu, V. (2020). Polymorphisms of the melatonin receptor 1A (MTNR1A) gene influence the age at first mating in autumn-born ram-lambs and sexual activity of adult rams in spring. Theriogenology, 157, 42-47.

Starič, J., Farci, F., Luridiana, S., Mura, M. C., Pulinas, L., Cosso, G., & Carcangiu, V. (2020). Reproductive performance in three Slovenian sheep breeds with different alleles for the MTNR1A gene. Animal reproduction science, 216, 106352.

Mura, M. C., Luridiana, S., Pulinas, L., Di Stefano, M. V., & Carcangiu, V. (2019). Reproductive response to male joining with ewes with different allelic variants of the MTNR1A gene. Animal reproduction science, 200, 67-74.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MTNR1A Recombinant Antibody (CBFYM-2754)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare