MXD1

MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. [provided by RefSeq]
Full Name
MAX dimerization protein 1
Function
Component of a transcriptional repressor complex together with MAX (PubMed:8425218).

In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218).

Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218).

Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.
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Anti-MXD1 antibodies

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Mouse Anti-MXD1 Recombinant Antibody (2G10) (CBMAB-A5701-LY)

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Target: MXD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G10
Application*: IH, E
Datasheet SDS

Mouse Anti-MXD1 (AA 324-498) Recombinant Antibody (CBFYM-2856) (CBMAB-M3049-FY)

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Target: MXD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2856
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2855) (CBMAB-M3048-FY)

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Target: MXD1
Host: Mouse
Specificity: Human
Clone: CBFYM-2855
Application*: WB
Datasheet SDS

Mouse Anti-MXD1 (AA 60-149) Recombinant Antibody (CBFYM-2854) (CBMAB-M3047-FY)

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Target: MXD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2854
Application*: P, E
Datasheet SDS

Mouse Anti-MXD1 (AA 60-150) Recombinant Antibody (CBFYM-2853) (CBMAB-M3046-FY)

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Target: MXD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2853
Application*: E
Datasheet SDS

Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2852) (CBMAB-M3045-FY)

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Target: MXD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2852
Application*: IC, IP, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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