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MXD1

MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. [provided by RefSeq]

Full Name

MAX dimerization protein 1

Function

Component of a transcriptional repressor complex together with MAX (PubMed:8425218).

In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218).

Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218).

Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246).

Biological Process

Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

PTM

Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.

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Anti-MXD1 antibodies

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Mouse Anti-MXD1 Recombinant Antibody (2G10) (CBMAB-A5701-LY)

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Target: MXD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G10

Application*: IH, E

Human MXD1 ELISA Kit (V2LY-0626-LY1820)

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Target: MXD1

Sensitivity: 0.0033 ng/mL

Detection Range: 0.007-1.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-MXD1 (AA 324-498) Recombinant Antibody (CBFYM-2856) (CBMAB-M3049-FY)

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Target: MXD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2856

Application*: IC, IP, WB

Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2855) (CBMAB-M3048-FY)

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Target: MXD1

Host: Mouse

Specificity: Human

Clone: CBFYM-2855

Application*: WB

Mouse Anti-MXD1 (AA 60-149) Recombinant Antibody (CBFYM-2854) (CBMAB-M3047-FY)

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Target: MXD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2854

Application*: P, E

Mouse Anti-MXD1 (AA 60-150) Recombinant Antibody (CBFYM-2853) (CBMAB-M3046-FY)

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Target: MXD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2853

Application*: E

Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2852) (CBMAB-M3045-FY)

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Target: MXD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-2852

Application*: IC, IP, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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