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MXD1

MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. [provided by RefSeq]

Full Name

MAX dimerization protein 1

Function

Component of a transcriptional repressor complex together with MAX (PubMed:8425218).

In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218).

Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218).

Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246).

Biological Process

Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

PTM

Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.

Anti-MXD1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-MXD1 Recombinant Antibody (2G10) (CBMAB-A5701-LY)

SDS

Target: MXD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G10

Application*: IH, E

Mouse Anti-MXD1 (AA 324-498) Recombinant Antibody (CBFYM-2856) (CBMAB-M3049-FY)

SDS

Target: MXD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2856

Application*: IC, IP, WB

Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2855) (CBMAB-M3048-FY)

SDS

Target: MXD1

Host: Mouse

Specificity: Human

Clone: CBFYM-2855

Application*: WB

Mouse Anti-MXD1 (AA 60-149) Recombinant Antibody (CBFYM-2854) (CBMAB-M3047-FY)

SDS

Target: MXD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2854

Application*: P, E

Mouse Anti-MXD1 (AA 60-150) Recombinant Antibody (CBFYM-2853) (CBMAB-M3046-FY)

SDS

Target: MXD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2853

Application*: E

Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2852) (CBMAB-M3045-FY)

SDS

Target: MXD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-2852

Application*: IC, IP, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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