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Mouse Anti-MXD1 Recombinant Antibody (2G10) (CBMAB-A5701-LY)

The product is antibody recognizes MXD1. The antibody 2G10 immunoassay techniques such as: IHC, ELISA.
See all MXD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G10
Antibody Isotype
IgG1, κ
Application
IHC, ELISA

Basic Information

Immunogen
MXD1 (NP_002348.1, 60 a.a. ~ 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAX dimerization protein 1
Introduction
MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. [provided by RefSeq]
Entrez Gene ID
4084
UniProt ID
Q05195
Alternative Names
MAD; MAD1; MGC104659
Function
Component of a transcriptional repressor complex together with MAX (PubMed:8425218).

In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218).

Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218).

Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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