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Mouse Anti-MXD1 Recombinant Antibody (CBFYM-2852) (CBMAB-M3045-FY)

This product is mouse antibody that recognizes MXD1. The antibody CBFYM-2852 can be used for immunoassay techniques such as: ICC, IP, WB.
See all MXD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2852
Antibody Isotype
IgG2b, k
Application
ICC, IP, WB

Basic Information

Immunogen
Full length recombinant Mad1. Cellular Localization: Nucleus.
Specificity
Human
Antibody Isotype
IgG2b, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAX dimerization protein 1
Introduction
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
4084
UniProt ID
Q05195
Alternative Names
MAX Dimerization Protein 1; Max Dimerizer 1; MAD; Antagonizer Of Myc Transcriptional Activity; MAX-Binding Protein; Protein MAD; BHLHC58; MAD1
Function
Component of a transcriptional repressor complex together with MAX (PubMed:8425218).

In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218).

Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218).

Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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