N
Signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Essential for proper differentiation of ectoderm. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. Rumi acts in the endoplasmic reticulum to glucosylate the EGF modules in N, this is required for correct folding and cleavage of N.
Full Name
Notch
Anti-N antibodies
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Target: N
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Common fruit fly
Clone: C17.9C6
Application*: IF, IH, IP, WB
Human respiratory syncytial virus Recombinant (RSV) Nucleoprotein protein, His Tag (V2LY-0526-LY262)
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Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-391
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-391
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-391
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-391
Tag: His & AVI Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-391
Tag: His Tag
Compare
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-450
Tag: His Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-413
Tag: His Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-560
Tag: His & AVI Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-560
Tag: His & AVI Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-498
Tag: His & AVI Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-498
Tag: His & AVI Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-498
Tag: His & AVI Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-498
Tag: His Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-498
Tag: His & AVI Tag
Target: N
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-490, 116
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-448
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-377
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-441
Tag: His Tag
Target: N
Expressed Host: E. coli
Sequence: Amino Acid: 1-389
Tag: His Tag
Target: N
Host: Mouse
Antibody Isotype: IgG1
Specificity: Common fruit fly
Clone: F461.3B
Application*: IF, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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