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Mouse Anti-N Antibody (C17.9C6) (CBMAB-1444CQ)

This product is a mouse antibody that recognizes N. The antibody C17.9C6 can be used for immunoassay techniques such as: IF, IHC, IP, WB.
See all N antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
C17.9C6
Antibody Isotype
IgG1, κ
Application
IF, IHC, IP, WB

Basic Information

Immunogen
Recombinant fusion protein containing aa 1791-2504 of the intracellular domain of Notch
Specificity
Common fruit fly
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Intracellular domain, aa 1791-2504

Target

Full Name
Notch
Introduction
Notch protein is signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Essential for proper differentiation of ectoderm. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. Rumi acts in the endoplasmic reticulum to glucosylate the EGF modules in N, this is required for correct folding and cleavage of N.
Entrez Gene ID
31293
UniProt ID
P07207
Alternative Names
1.1; 16-178; 16-55; anon-EST:Liang-1.12; Ax; CG3936; Chp; clone 1.12; co; Co; CT13012; Dmel\CG3936; dNotch; EG:140G11.1; EG:163A10.2; fa; l(1)3Cb; l(1)Ax; l(1)N; nd; NECD; NICD; notch; n[fah]; RICN; shd; spl; swb
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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