NANOS2

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Full Name

Nanos C2HC-Type Zinc Finger 2

Function

Biological Process

Germ-line stem cell population maintenance Source: UniProtKB
mRNA catabolic process Source: UniProtKB
Negative regulation of meiotic nuclear division Source: UniProtKB
Negative regulation of translation Source: BHF-UCL
Oogenesis Source: GO_Central
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: BHF-UCL
Spermatogenesis Source: UniProtKB

Cellular Location

Cytoplasm
Other locations
P-body
perinuclear region
Note: Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis.