NANOS3

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

nanos homolog 3 (Drosophila)

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Germ cell development Source: UniProtKB
Negative regulation of apoptotic signaling pathway Source: Ensembl
Negative regulation of translation Source: BHF-UCL
Oogenesis Source: GO_Central
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: BHF-UCL
Regulation of cell cycle Source: UniProtKB
Regulation of translation Source: UniProtKB
Spermatogenesis Source: UniProtKB

Cytoplasm
Nucleus
Other locations
Stress granule
P-body
Note: Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body.