NCK2

This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Full Name

NCK Adaptor Protein 2

Function

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Biological Process

Actin filament organization Source: Ensembl
Cell migration Source: GO_Central
Dendritic spine development Source: Ensembl
Ephrin receptor signaling pathway Source: Ensembl
Epidermal growth factor receptor signaling pathway Source: ProtInc
Immunological synapse formation Source: Ensembl
Lamellipodium assembly Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of PERK-mediated unfolded protein response Source: GO_Central
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: Ensembl
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: GO_Central
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of translation in response to endoplasmic reticulum stress Source: GO_Central
Regulation of epidermal growth factor-activated receptor activity Source: ProtInc
Signal complex assembly Source: UniProtKB
Signal transduction Source: GO_Central
T cell activation Source: UniProtKB

Cellular Location

Cytoplasm
Endoplasmic reticulum

PTM

Phosphorylated.