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Mouse Anti-NCK2 Recombinant Antibody (AF3F11) (CBMAB-N1413-WJ)

This product is a Mouse antibody that recognizes NCK2. The antibody AF3F11 can be used for immunoassay techniques such as: IP, WB.
See all NCK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
AF3F11
Antibody Isotype
IgG1, κ
Application
IP, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, 0.15M sodium chloride, 0.01% BSA, 50% glycerol
Preservative
0.03% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NCK Adaptor Protein 2
Introduction
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human8440
Mouse17974
Rat316369
UniProt ID
HumanO43639
MouseO55033
RatD4A3M8
Alternative Names
NCK Adaptor Protein 2; Growth Factor Receptor-Bound Protein 4; SH2/SH3 Adaptor Protein NCK-Beta; GRB4; Noncatalytic Region Of Tyrosine Kinase, Beta; Cytoplasmic Protein NCK2; NCKbeta; Nck-2;
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Biological Process
Actin filament organization Source: Ensembl
Cell migration Source: GO_Central
Dendritic spine development Source: Ensembl
Ephrin receptor signaling pathway Source: Ensembl
Epidermal growth factor receptor signaling pathway Source: ProtInc
Immunological synapse formation Source: Ensembl
Lamellipodium assembly Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of PERK-mediated unfolded protein response Source: GO_Central
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: Ensembl
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: GO_Central
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of translation in response to endoplasmic reticulum stress Source: GO_Central
Regulation of epidermal growth factor-activated receptor activity Source: ProtInc
Signal complex assembly Source: UniProtKB
Signal transduction Source: GO_Central
T cell activation Source: UniProtKB
Cellular Location
Cytoplasm
Endoplasmic reticulum
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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