NCKIPSD

The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]
Full Name
NCK interacting protein with SH3 domain
Function
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity).

In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity).

May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.
Biological Process
Cytoskeleton organization Source: UniProtKB
Endocytosis Source: GO_Central
Positive regulation of neuron projection development Source: Ensembl
Cellular Location
Nucleus
Note: Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
PTM
A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.
View more

Anti-NCKIPSD antibodies

+ Filters
Loading...

Mouse Anti-NCKIPSD Recombinant Antibody (CBXS-2064) (CBMAB-S4830-CQ)

Go to compareCompare
Target: NCKIPSD
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2064
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NCKIPSD Recombinant Antibody (CBXS-5127) (CBMAB-S2345-CQ)

Go to compareCompare
Target: NCKIPSD
Host: Mouse
Specificity: Human
Clone: CBXS-5127
Application*: WB, IP
Datasheet SDS

Mouse Anti-NCKIPSD Recombinant Antibody (CBWJN-1213) (CBMAB-N1417-WJ)

Go to compareCompare
Target: NCKIPSD
Host: Mouse
Specificity: Human
Clone: CBWJN-1213
Application*: WB
Datasheet SDS

Mouse Anti-NCKIPSD Recombinant Antibody (2E4) (CBMAB-N1415-WJ)

Go to compareCompare
Target: NCKIPSD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E4
Application*: E
Datasheet SDS

Mouse Anti-NCKIPSD Recombinant Antibody (CBWJN-0309) (CBMAB-N0169-WJ)

Go to compareCompare
Target: NCKIPSD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0309
Application*: WB, DB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry