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NCKIPSD

The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

Full Name

NCK interacting protein with SH3 domain

Function

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity).

In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity).

May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.

Biological Process

Cytoskeleton organization Source: UniProtKB
Endocytosis Source: GO_Central
Positive regulation of neuron projection development Source: Ensembl

Cellular Location

Nucleus
Note: Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.

PTM

A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.

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Anti-NCKIPSD antibodies

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Mouse Anti-NCKIPSD Recombinant Antibody (CBXS-2064) (CBMAB-S4830-CQ)

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Target: NCKIPSD

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-2064

Application*: WB, IP, IF, E

Mouse Anti-NCKIPSD Recombinant Antibody (CBXS-5127) (CBMAB-S2345-CQ)

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Target: NCKIPSD

Host: Mouse

Specificity: Human

Clone: CBXS-5127

Application*: WB, IP

Mouse Anti-NCKIPSD Recombinant Antibody (CBWJN-1213) (CBMAB-N1417-WJ)

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Target: NCKIPSD

Host: Mouse

Specificity: Human

Clone: CBWJN-1213

Application*: WB

Mouse Anti-NCKIPSD Recombinant Antibody (2E4) (CBMAB-N1415-WJ)

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Target: NCKIPSD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E4

Application*: E

Mouse Anti-NCKIPSD Recombinant Antibody (CBWJN-0309) (CBMAB-N0169-WJ)

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Target: NCKIPSD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0309

Application*: WB, DB

Human Recombinant NCKIPSD protein, GST Tag (V2LY-0526-LY5709)

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Target: NCKIPSD

Expressed Host: E. coli

Sequence: Amino Acid: 1-244

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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