NCR3

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Full Name
Natural Cytotoxicity Triggering Receptor 3
Function
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Biological Process
Cell recognition Source: BHF-UCL
Immune response Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 19-135
Helical: 136-156
Cytoplasmic: 157-201
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Anti-NCR3 antibodies

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Mouse Anti-NCR3 Recombinant Antibody (CBT2287) (V2LY-0625-LY1570)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2287
Application*: F
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (CBT4347) (V2LY-0625-LY1569)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4347
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (AF29-4D12) (CBMAB-C1715-CQ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AF29-4D12
Application*: F
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (y4E6) (CBMAB-N1509-WJ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: y4E6
Application*: E, WB
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (P30-15) (CBMAB-N1507-WJ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P30-15
Application*: E, F
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (CBWJN-0228) (CBMAB-N1504-WJ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0228
Application*: F
Datasheet SDS

Rabbit Anti-NCR3 Recombinant Antibody (CBWJN-1229) (CBMAB-N1501-WJ)

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Target: NCR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1229
Application*: E
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (CBWJN-0673) (CBMAB-N0200-WJ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0673
Application*: F, MC
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (B-S30) (CBMAB-N0199-WJ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: B-S30
Application*: FN
Datasheet SDS

Mouse Anti-NCR3 Recombinant Antibody (CBWJN-0961) (CBMAB-N0198-WJ)

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Target: NCR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0961
Application*: F, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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