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Mouse Anti-NCR3 Recombinant Antibody (CBT2287) (V2LY-0625-LY1570)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2287
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD337 (AA: extra 19-135) expressed in HEK293-6e cells supernatant.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Natural Cytotoxicity Triggering Receptor 3
Entrez Gene ID
259197
UniProt ID
O14931
Function
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Biological Process
Cell recognition Source: BHF-UCL
Immune response Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 19-135
Helical: 136-156
Cytoplasmic: 157-201
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For research use only. Not intended for any clinical use.

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