Human NCR3 ELISA Kit (V2LY-0626-LY4932)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0045 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
21.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Natural Cytotoxicity Triggering Receptor 3
Function
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Biological Process
Cell recognition Source: BHF-UCL
Immune response Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 19-135
Helical: 136-156
Cytoplasmic: 157-201

Onyango, C. O., Cheng, Q., Munde, E. O., Raballah, E., Anyona, S. B., McMahon, B. H., ... & Ouma, C. (2023). Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia. BMC genomics, 24(1), 542.

DIRO, M. J. (2019). Association between Natural Cytotoxicity Triggering Receptor-3 Polymorphisms (-172a/G and-412c/G) and Interferon-Gamma Levels in Children Aged 3-36 Months with Severe Plasmodium Falciparum Anaemia at Siaya County Referral Hospital in Western Kenya (Doctoral dissertation, Maseno University).

Mantovani, S., Oliviero, B., Lombardi, A., Varchetta, S., Mele, D., Sangiovanni, A., ... & Mondelli, M. U. (2019). Deficient natural killer cell NKp30‐mediated function and altered NCR3 splice variants in hepatocellular carcinoma. Hepatology, 69(3), 1165-1179.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NCR3 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5799)

Human Recombinant NCR3 protein, His Tag (CAT#: V2LY-0526-LY5800)

Cynomolgus, Rhesus Recombinant NCR3 protein, His Tag (CAT#: V2LY-0526-LY1731)

Rat Recombinant NCR3 protein, ECD, His Tag (CAT#: V2LY-0526-LY9533)

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Mouse Anti-NCR3 Recombinant Antibody (AF29-4D12) (CAT#: CBMAB-C1715-CQ)

Mouse Anti-NCR3 Recombinant Antibody (P30-15) (CAT#: CBMAB-N1507-WJ)

Mouse Anti-NCR3 Recombinant Antibody (CBT4347) (CAT#: V2LY-0625-LY1569)

Human Recombinant NCR3 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5799)

Cynomolgus, Rhesus Recombinant NCR3 protein, His Tag (CAT#: V2LY-0526-LY1731)

Human Recombinant NCR3 protein, His Tag (CAT#: V2LY-0526-LY5800)

Mouse Anti-NCR3 Recombinant Antibody (B-S30) (CAT#: CBMAB-N0199-WJ)

Mouse Anti-NCR3 Recombinant Antibody (y4E6) (CAT#: CBMAB-N1509-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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