Mouse Anti-NCR3 Recombinant Antibody (AF29-4D12) (CBMAB-C1715-CQ)

Name: Mouse Anti-NCR3 Recombinant Antibody (AF29-4D12)
SKU: CBMAB-C1715-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

AF29-4D12

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Buffer containing stabilizer

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Natural Cytotoxicity Triggering Receptor 3

Introduction

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

259197

UniProt ID

O14931

Alternative Names

Natural Cytotoxicity Triggering Receptor 3; Natural Killer Cell P30-Related Protein; Activating Natural Killer Receptor P30; Lymphocyte Antigen 117; NK-P30; LY117; NKp30;

Function

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Biological Process

Cell recognition Source: BHF-UCL
Immune response Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 19-135
Helical: 136-156
Cytoplasmic: 157-201

Onyango, C. O., Cheng, Q., Munde, E. O., Raballah, E., Anyona, S. B., McMahon, B. H., ... & Ouma, C. (2023). Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia. BMC genomics, 24(1), 542.

DIRO, M. J. (2019). Association between Natural Cytotoxicity Triggering Receptor-3 Polymorphisms (-172a/G and-412c/G) and Interferon-Gamma Levels in Children Aged 3-36 Months with Severe Plasmodium Falciparum Anaemia at Siaya County Referral Hospital in Western Kenya (Doctoral dissertation, Maseno University).

Mantovani, S., Oliviero, B., Lombardi, A., Varchetta, S., Mele, D., Sangiovanni, A., ... & Mondelli, M. U. (2019). Deficient natural killer cell NKp30‐mediated function and altered NCR3 splice variants in hepatocellular carcinoma. Hepatology, 69(3), 1165-1179.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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