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Mouse Anti-NCR3 Recombinant Antibody (AF29-4D12) (CBMAB-C1715-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
AF29-4D12
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Natural Cytotoxicity Triggering Receptor 3
Introduction
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
259197
UniProt ID
O14931
Alternative Names
Natural Cytotoxicity Triggering Receptor 3; Natural Killer Cell P30-Related Protein; Activating Natural Killer Receptor P30; Lymphocyte Antigen 117; NK-P30; LY117; NKp30;
Function
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Biological Process
Cell recognition Source: BHF-UCL
Immune response Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 19-135
Helical: 136-156
Cytoplasmic: 157-201
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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