NECAB2

The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]

Full Name

N-Terminal EF-Hand Calcium Binding Protein 2

Function

May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.

Biological Process

Negative regulation of G protein-coupled receptor internalization Source: UniProtKB
Positive regulation of adenosine receptor signaling pathway Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of glutamate receptor signaling pathway Source: UniProtKB
Positive regulation of protein localization to membrane Source: UniProtKB
Regulation of amyloid precursor protein biosynthetic process Source: GO_Central

Cellular Location

Cytoplasm
Plasma membrane
Cell membrane
Other locations
dendrite
axon
Note: Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity).