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Mouse Anti-NECAB2 Recombinant Antibody (CL0524) (CBMAB-E2213-FY)

This product is mouse antibody that recognizes NECAB2. The antibody CL0524 can be used for immunoassay techniques such as: IHC, IHC-P.
See all NECAB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CL0524
Antibody Isotype
IgG1
Application
IHC, IHC-P

Basic Information

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: ATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGVRNCFHITAVRLSDGFTFVIYEFWETEEAWKRHLQSPLCKAFRHVKVDTLSQPEALSRILVPA
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-Terminal EF-Hand Calcium Binding Protein 2
Introduction
The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5.
Entrez Gene ID
UniProt ID
Alternative Names
N-Terminal EF-Hand Calcium Binding Protein 2; Synaptotagmin-Interacting Protein 2; Neuronal Calcium-Binding Protein 2; EF-Hand Calcium-Binding Protein 2; Stip-2; EFCBP2; N-Terminal EF-Hand Calcium-Binding Protein 2; EF-Hand Calcium Binding Protein 2; Neuronal Calcium Binding 2
Function
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Biological Process
Negative regulation of G protein-coupled receptor internalization Source: UniProtKB
Positive regulation of adenosine receptor signaling pathway Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of glutamate receptor signaling pathway Source: UniProtKB
Positive regulation of protein localization to membrane Source: UniProtKB
Regulation of amyloid precursor protein biosynthetic process Source: GO_Central
Cellular Location
Cytoplasm
Plasma membrane
Cell membrane
Other locations
dendrite
axon
Note: Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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