NFATC3
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Full Name
NFATC3
Function
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128).
Along with NFATC4, involved in embryonic heart development (By similarity).
Along with NFATC4, involved in embryonic heart development (By similarity).
Biological Process
Calcineurin-NFAT signaling cascade Source: GO_Central
Inflammatory response Source: ProtInc
Negative regulation of miRNA transcription Source: BHF-UCL
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Inflammatory response Source: ProtInc
Negative regulation of miRNA transcription Source: BHF-UCL
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
PTM
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
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Anti-NFATC3 antibodies
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CompareTarget: NFATC3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A12
Application*: E, IF, IH
Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A12
Application*: CI, IP, WB, M
Target: NFATC3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBWJN-0805
Application*: WB
Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TS106
Application*: WB
Target: NFATC3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: F-1
Application*: WB, IP, IF, P, E
Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0093
Application*: WB
Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0395
Application*: DB, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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