NFATC3

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Full Name
NFATC3
Function
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128).

Along with NFATC4, involved in embryonic heart development (By similarity).
Biological Process
Calcineurin-NFAT signaling cascade Source: GO_Central
Inflammatory response Source: ProtInc
Negative regulation of miRNA transcription Source: BHF-UCL
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
PTM
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
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Anti-NFATC3 antibodies

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Mouse Anti-NFATC3 Recombinant Antibody (3A12) (CBMAB-N2170-WJ)

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Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A12
Application*: E, IF, IH
Datasheet SDS

Mouse Anti-NFATC3 Antibody (2A12) (CBMAB-0717-YC)

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Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A12
Application*: CI, IP, WB, M
Datasheet SDS

Rat Anti-NFATC3 Recombinant Antibody (CBWJN-0805) (CBMAB-N2174-WJ)

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Target: NFATC3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBWJN-0805
Application*: WB
Datasheet SDS

Mouse Anti-NFATC3 Recombinant Antibody (TS106) (CBMAB-N2173-WJ)

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Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TS106
Application*: WB
Datasheet SDS

Mouse Anti-NFATC3 Recombinant Antibody (F-1) (CBMAB-N2172-WJ)

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Target: NFATC3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: F-1
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-NFATC3 Recombinant Antibody (CBWJN-0093) (CBMAB-N2169-WJ)

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Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0093
Application*: WB
Datasheet SDS

Mouse Anti-NFATC3 Recombinant Antibody (CBWJN-0395) (CBMAB-N0300-WJ)

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Target: NFATC3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0395
Application*: DB, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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