NHLH2

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

Full Name

Nescient Helix-Loop-Helix 2

Function

Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN and PCSK1. May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons.

Biological Process

Apoptotic processIEA:Ensembl
Cell migration in hindbrainIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Hypothalamus gonadotrophin-releasing hormone neuron developmentIEA:Ensembl
Male gonad developmentIEA:Ensembl
Male mating behaviorIEA:Ensembl
Ovulation cycleIEA:Ensembl
Peripheral nervous system developmentIEA:Ensembl
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus