NKX6-1

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Full Name

Nkx6-1

Function

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity).
Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to cytokine stimulusIEA:Ensembl
Cellular response to peptide hormone stimulusIEA:Ensembl
Central nervous system neuron differentiationIEA:Ensembl
Detection of glucoseISS:BHF-UCL
Negative regulation of glial cell differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Neuron migrationIEA:InterPro
Oligodendrocyte differentiationIEA:Ensembl
Pancreas developmentISS:BHF-UCL
Positive regulation of DNA-binding transcription factor activityISS:BHF-UCL
Positive regulation of glial cell differentiationIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of type B pancreatic cell developmentISS:BHF-UCL
Regulation of axon extensionIEA:Ensembl
Regulation of neuron migrationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to nicotineIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl
Type B pancreatic cell maturationISS:BHF-UCL
Type B pancreatic cell proliferationISS:UniProtKB

Cellular Location

Nucleus