Sign in or Register   Sign in or Register
  |  

Mouse Anti-NKX6-1 Recombinant Antibody (R11-560) (CBMAB-N0408-WJ)

This product is a Mouse antibody that recognizes NKX6-1. The antibody R11-560 can be used for immunoassay techniques such as: WB, Bioimaging, ICFC, IF.
See all NKX6-1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
R11-560
Antibody Isotype
IgG1, κ
Application
WB, Bioimaging, ICFC, IF

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nkx6-1
Introduction
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human4825
Mouse18096
UniProt ID
HumanP78426
MouseQ99MA9
Alternative Names
NK6 Homeobox 1; Homeobox Protein NK-6 Homolog A; NKX6A; NK6 Transcription Factor Related, Locus 1 (Drosophila); NK6 Transcription Factor Related, Locus 1; NK Homeobox (Drosophila), Family 6, A;
Function
Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity).
Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to cytokine stimulusIEA:Ensembl
Cellular response to peptide hormone stimulusIEA:Ensembl
Central nervous system neuron differentiationIEA:Ensembl
Detection of glucoseISS:BHF-UCL
Negative regulation of glial cell differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Neuron migrationIEA:InterPro
Oligodendrocyte differentiationIEA:Ensembl
Pancreas developmentISS:BHF-UCL
Positive regulation of DNA-binding transcription factor activityISS:BHF-UCL
Positive regulation of glial cell differentiationIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of type B pancreatic cell developmentISS:BHF-UCL
Regulation of axon extensionIEA:Ensembl
Regulation of neuron migrationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to nicotineIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl
Type B pancreatic cell maturationISS:BHF-UCL
Type B pancreatic cell proliferationISS:UniProtKB
Cellular Location
Nucleus

Pavluch, V., Engstová, H., Špačková, J., & Ježek, P. (2023). Deficiency of transcription factor Nkx6. 1 does not prevent insulin secretion in INS-1E cells. Scientific Reports, 13(1), 683.

Xie, B., Tong, K., Yang, J., Wang, T., Cheng, L., Zeng, S., & Hu, Z. (2022). NKX6-1 is a less sensitive but specific biomarker of chromophobe renal cell carcinoma. The American Journal of Surgical Pathology, 46(6), 809-815.

Patel, M., Anderson, J., Lei, S., Finkel, Z., Rodriguez, B., Esteban, F., ... & Cai, L. (2021). Nkx6. 1 enhances neural stem cell activation and attenuates glial scar formation and neuroinflammation in the adult injured spinal cord. Experimental neurology, 345, 113826.

Fujita, Y., Kozawa, J., Fukui, K., Iwahashi, H., Eguchi, H., & Shimomura, I. (2021). Increased NKX6. 1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects. Scientific Reports, 11(1), 17796.

Memon, B., Younis, I., Abubaker, F., & Abdelalim, E. M. (2021). PDX1−/NKX6. 1+ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells. Diabetes/Metabolism Research and Reviews, 37(5), e3400.

Zhang, F. F., Liu, Y. H., Wang, D. W., Liu, T. S., Yang, Y., Guo, J. M., ... & Jin, L. (2020). Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6. 1 methylation. Diabetologia, 63, 811-824.

Aigha, I. I., & Abdelalim, E. M. (2020). NKX6. 1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation. Stem Cell Research & Therapy, 11(1), 1-14.

Chung, H. H., Lee, C. T., Hu, J. M., Chou, Y. C., Lin, Y. W., & Shih, Y. L. (2020). NKX6. 1 represses tumorigenesis, metastasis, and chemoresistance in colorectal cancer. International Journal of Molecular Sciences, 21(14), 5106.

Tran, R., Moraes, C., & Hoesli, C. A. (2020). Controlled clustering enhances PDX1 and NKX6. 1 expression in pancreatic endoderm cells derived from pluripotent stem cells. Scientific reports, 10(1), 1190.

Padula, S. L., Anand, D., Hoang, T. V., Chaffee, B. R., Liu, L., Liang, C., ... & Robinson, M. L. (2019). High-throughput transcriptome analysis reveals that the loss of Pten activates a novel NKX6-1/RASGRP1 regulatory module to rescue microphthalmia caused by Fgfr2-deficient lenses. Human genetics, 138, 1391-1407.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NKX6-1 Recombinant Antibody (R11-560)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare