NME2

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product.
Full Name
NME2
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197).
Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876).
Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III1 region of the MYC gene promoter. Does not bind to duplex NHE III1 (PubMed:19435876).
Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041).
Exhibits histidine protein kinase activity (PubMed:20946858).
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:HGNC-UCL
CTP biosynthetic processIEA:InterPro
GTP biosynthetic processIEA:InterPro
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:HGNC-UCL
Nucleoside diphosphate phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Nucleoside triphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentIMP:HGNC-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of epidermis developmentManual Assertion Based On ExperimentIMP:HGNC-UCL
UTP biosynthetic processIEA:InterPro
Cellular Location
Cytoplasm
Cell projection, lamellipodium
Cell projection, ruffle
Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Isoform 1
Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Isoform 3
Cytoplasm
Cytoplasm, perinuclear region
Nucleus
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Anti-NME2 antibodies

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Mouse Anti-NME2 Recombinant Antibody (KM1103) (CBMAB-N2777-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: KM1103
Application*: C, IA, WB
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (CBWJN-0408) (CBMAB-N2776-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0408
Application*: E, WB
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (4A7) (CBMAB-N2775-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4A7
Application*: E, WB
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (2F9) (CBMAB-N2774-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F9
Application*: WB
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (1D4) (CBMAB-N2773-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1D4
Application*: E, WB
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (1D3) (CBMAB-N2772-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1D3
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (1A9) (CBMAB-N2771-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1A9
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-NME2 Recombinant Antibody (CBWJN-1004) (CBMAB-N0429-WJ)

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Target: NME2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1004
Application*: WB, P, F, IC
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (4G7A8) (CBMAB-N0428-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G7A8
Application*: WB, E, IH, P
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (1F2) (CBMAB-N0427-WJ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1F2
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-NME2 Antibody (9BA22) (CBMAB-1465CQ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9BA22
Application*: E, WB
Datasheet SDS

Mouse Anti-NME2 Antibody (9BA21) (CBMAB-1464CQ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 9BA21
Application*: E, IH, M
Datasheet SDS

Mouse Anti-NME2 Antibody (9BA20) (CBMAB-1463CQ)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 9BA20
Application*: E
Datasheet SDS

Mouse Anti-NME2 Recombinant Antibody (CBT4178) (V2LY-0625-LY170)

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Target: NME2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4178
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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