NOXA1

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Full Name

NADPH Oxidase Activator 1

Function

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Biological Process

Regulation of hydrogen peroxide metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of respiratory burstManual Assertion Based On ExperimentIMP:BHF-UCL
Superoxide anion generationManual Assertion Based On ExperimentIBA:GO_Central
Superoxide metabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Cell membrane
Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

PTM

Interaction with YWHAZ depends on phosphorylation by PKA.