Mouse Anti-NOXA1 Recombinant Antibody (H-6) (CBMAB-N3087-WJ)

Name: Mouse Anti-NOXA1 Recombinant Antibody (H-6)
SKU: CBMAB-N3087-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

H-6

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NADPH Oxidase Activator 1

Introduction

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Entrez Gene ID

10811

UniProt ID

Q86UR1

Alternative Names

NADPH Oxidase Activator 1; Serologically Defined Colon Cancer Antigen 31; P67phox-Like Factor; NCF2-Like Protein; Antigen NY-CO-31; P51-Nox; P51NOX;

Function

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Biological Process

Regulation of hydrogen peroxide metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of respiratory burstManual Assertion Based On ExperimentIMP:BHF-UCL
Superoxide anion generationManual Assertion Based On ExperimentIBA:GO_Central
Superoxide metabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Cell membrane
Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

PTM

Interaction with YWHAZ depends on phosphorylation by PKA.

Stevenson, M. D., Vendrov, A. E., Yang, X., Chen, Y., Navarro, H. A., Moss, N., ... & Madamanchi, N. R. (2023). Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling. American Journal of Physiology-Renal Physiology, 324(4), F335-F352.

Vendrov, A. E., Stevenson, M. D., Lozhkin, A., Hayami, T., Holland, N. A., Yang, X., ... & Arendshorst, W. J. (2022). Renal NOXA1/NOX1 signaling regulates epithelial sodium channel and sodium retention in angiotensin II-induced hypertension. Antioxidants & Redox Signaling, 36(7-9), 550-566.

Mironova, E., Archer, C. R., Vendrov, A. E., Runge, M. S., Madamanchi, N. R., Arendshorst, W. J., ... & Abd El-Aziz, T. M. (2022). NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel. American Journal of Physiology-Renal Physiology, 323(6), F633-F641.

Tang, Y., Song, H., Shen, Y., Yao, Y., Yu, Y., Wei, G., ... & Yan, W. (2021). MiR-155 acts as an inhibitory factor in atherosclerosis-associated arterial pathogenesis by down-regulating NoxA1 related signaling pathway in ApoE−/− mouse. Cardiovascular Diagnosis and Therapy, 11(1), 1.

Attri, P., Park, J. H., De Backer, J., Kim, M., Yun, J. H., Heo, Y., ... & Bogaerts, A. (2020). Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. International Journal of Biological Macromolecules, 163, 2405-2414.

Orr, A. W., & Woolard, M. D. (2019). Cardiovascular disease is obNOXious: New insights into NoxA1 in smooth muscle phenotype. Redox Biology, 22.

Vendrov, A. E., Sumida, A., Canugovi, C., Lozhkin, A., Hayami, T., Madamanchi, N. R., & Runge, M. S. (2019). NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. Redox Biology, 21, 101063.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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