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Mouse Anti-NOXA1 Recombinant Antibody (H-6) (CBMAB-N3087-WJ)

This product is a Mouse antibody that recognizes NOXA1. The antibody H-6 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NOXA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
H-6
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NADPH Oxidase Activator 1
Introduction
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Entrez Gene ID
10811
UniProt ID
Q86UR1
Alternative Names
NADPH Oxidase Activator 1; Serologically Defined Colon Cancer Antigen 31; P67phox-Like Factor; NCF2-Like Protein; Antigen NY-CO-31; P51-Nox; P51NOX;
Function
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Biological Process
Regulation of hydrogen peroxide metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of respiratory burstManual Assertion Based On ExperimentIMP:BHF-UCL
Superoxide anion generationManual Assertion Based On ExperimentIBA:GO_Central
Superoxide metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
PTM
Interaction with YWHAZ depends on phosphorylation by PKA.

Stevenson, M. D., Vendrov, A. E., Yang, X., Chen, Y., Navarro, H. A., Moss, N., ... & Madamanchi, N. R. (2023). Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling. American Journal of Physiology-Renal Physiology, 324(4), F335-F352.

Vendrov, A. E., Stevenson, M. D., Lozhkin, A., Hayami, T., Holland, N. A., Yang, X., ... & Arendshorst, W. J. (2022). Renal NOXA1/NOX1 signaling regulates epithelial sodium channel and sodium retention in angiotensin II-induced hypertension. Antioxidants & Redox Signaling, 36(7-9), 550-566.

Mironova, E., Archer, C. R., Vendrov, A. E., Runge, M. S., Madamanchi, N. R., Arendshorst, W. J., ... & Abd El-Aziz, T. M. (2022). NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel. American Journal of Physiology-Renal Physiology, 323(6), F633-F641.

Tang, Y., Song, H., Shen, Y., Yao, Y., Yu, Y., Wei, G., ... & Yan, W. (2021). MiR-155 acts as an inhibitory factor in atherosclerosis-associated arterial pathogenesis by down-regulating NoxA1 related signaling pathway in ApoE−/− mouse. Cardiovascular Diagnosis and Therapy, 11(1), 1.

Attri, P., Park, J. H., De Backer, J., Kim, M., Yun, J. H., Heo, Y., ... & Bogaerts, A. (2020). Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. International Journal of Biological Macromolecules, 163, 2405-2414.

Orr, A. W., & Woolard, M. D. (2019). Cardiovascular disease is obNOXious: New insights into NoxA1 in smooth muscle phenotype. Redox Biology, 22.

Vendrov, A. E., Sumida, A., Canugovi, C., Lozhkin, A., Hayami, T., Madamanchi, N. R., & Runge, M. S. (2019). NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. Redox Biology, 21, 101063.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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