NQO2
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Full Name
N-Ribosyldihydronicotinamide:Quinone Reductase 2
Function
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Biological Process
Quinone catabolic processManual Assertion Based On ExperimentIDA:CAFA
Cellular Location
Cytoplasm
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Anti-NQO2 antibodies
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Target: NQO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E8-G2
Application*: WB, E
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0766
Application*: E, WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: AT1E3
Application*: E, WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F6
Application*: IF, WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B2
Application*: WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey, Mouse
Clone: 3G4
Application*: WB, IH, P
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0366
Application*: E, WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 3C11
Application*: WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A7
Application*: WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 1G2
Application*: IF, P, WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11H4
Application*: E, WB
Target: NQO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1E3
Application*: WB, E
Target: NQO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 8E12
Application*: E, WB
Target: NQO2
Specificity: Human
Target: NQO2
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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