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NTN4

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Full Name

Netrin 4

Function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Neuron remodelingIEA:Ensembl
Regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalingIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

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Anti-NTN4 antibodies

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Mouse Anti-NTN4 Recombinant Antibody (CBWJN-0737) (CBMAB-N3764-WJ)

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Target: NTN4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0737

Application*: E, IP, WB

Mouse Anti-NTN4 Recombinant Antibody (CBWJN-0222) (CBMAB-N3761-WJ)

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Target: NTN4

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBWJN-0222

Application*: WB

Rat Anti-NTN4 Recombinant Antibody (CBWJN-1575) (CBMAB-N3760-WJ)

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Target: NTN4

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBWJN-1575

Application*: WB

Mouse Anti-NTN4 Recombinant Antibody (CBWJN-0734) (CBMAB-N0552-WJ)

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Target: NTN4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0734

Application*: E, WB

Mouse Anti-NTN4 Recombinant Antibody (CBWJN-1037) (CBMAB-N0551-WJ)

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Target: NTN4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-1037

Application*: WB, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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