Rat Anti-NTN4 Recombinant Antibody (CBWJN-1575) (CBMAB-N3760-WJ)

Name: Rat Anti-NTN4 Recombinant Antibody (CBWJN-1575)
SKU: CBMAB-N3760-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBWJN-1575

Application

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Netrin 4

Introduction

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Entrez Gene ID

Human	59277
Mouse	57764

UniProt ID

Human	Q9HB63
Mouse	Q9JI33

Alternative Names

Netrin 4; Beta-Netrin; Hepar-Derived Netrin-Like Protein; Netrin-4; PRO3091;

Function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Neuron remodelingIEA:Ensembl
Regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalingIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

Ke, S., Guo, J., Wang, Q., Shao, H., He, M., Li, T., ... & Guo, J. (2023). Netrin family genes as prognostic markers and therapeutic targets for clear cell renal cell carcinoma: netrin-4 acts through the Wnt/β-catenin signaling pathway. Cancers, 15(10), 2816.

Wu, Z., Liu, S., Pang, G., & Jiang, H. (2023). RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression. Oncology Reports, 50(5), 1-11.

Dong, F., Liu, Y., Yan, W., Meng, Q., Song, X., Cheng, B., & Yao, R. (2023). Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors. Cellular and Molecular Neurobiology, 43(5), 1663-1683.

Zhang, H., Vreeken, D., Leuning, D. G., Bruikman, C. S., Junaid, A., Stam, W., ... & van Gils, J. M. (2021). Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence. The International Journal of Biochemistry & Cell Biology, 134, 105960.

Crespo-Garcia, S., Reichhart, N., Kociok, N., Skosyrski, S., & Joussen, A. M. (2021). Anti-inflammatory role of netrin-4 in diabetic retinopathy. International Journal of Molecular Sciences, 22(9), 4481.

Lee, N. G., Jeung, I. C., Heo, S. C., Song, J., Kim, W., Hwang, B., ... & Min, J. K. (2020). Ischemia‐induced Netrin‐4 promotes neovascularization through endothelial progenitor cell activation via Unc‐5 Netrin receptor B. The FASEB Journal, 34(1), 1231-1246.

Villanueva, A. A., Puvogel, S., Lois, P., Muñoz-Palma, E., Ramírez Orellana, M., Lubieniecki, F., ... & Palma, V. (2019). The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells. Cell Adhesion & Migration, 13(1), 33-40.

Crespo-Garcia, S., Reichhart, N., Wigdahl, J., Skosyrski, S., Kociok, N., Strauß, O., & Joussen, A. M. (2019). Lack of netrin-4 alters vascular remodeling in the retina. Graefe's Archive for Clinical and Experimental Ophthalmology, 257, 2179-2184.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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