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Mouse Anti-NTN4 Recombinant Antibody (CBWJN-1037) (CBMAB-N0551-WJ)

This product is a Mouse antibody that recognizes NTN4. The antibody CBWJN-1037 can be used for immunoassay techniques such as: WB, ELISA.
See all NTN4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1037
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Netrin 4
Introduction
This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Entrez Gene ID
59277
UniProt ID
Q9HB63
Alternative Names
Netrin 4; Beta-Netrin; Hepar-Derived Netrin-Like Protein; Netrin-4; PRO3091;
Function
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Neuron remodelingIEA:Ensembl
Regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalingIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

Ke, S., Guo, J., Wang, Q., Shao, H., He, M., Li, T., ... & Guo, J. (2023). Netrin family genes as prognostic markers and therapeutic targets for clear cell renal cell carcinoma: netrin-4 acts through the Wnt/β-catenin signaling pathway. Cancers, 15(10), 2816.

Wu, Z., Liu, S., Pang, G., & Jiang, H. (2023). RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression. Oncology Reports, 50(5), 1-11.

Dong, F., Liu, Y., Yan, W., Meng, Q., Song, X., Cheng, B., & Yao, R. (2023). Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors. Cellular and Molecular Neurobiology, 43(5), 1663-1683.

Zhang, H., Vreeken, D., Leuning, D. G., Bruikman, C. S., Junaid, A., Stam, W., ... & van Gils, J. M. (2021). Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence. The International Journal of Biochemistry & Cell Biology, 134, 105960.

Crespo-Garcia, S., Reichhart, N., Kociok, N., Skosyrski, S., & Joussen, A. M. (2021). Anti-inflammatory role of netrin-4 in diabetic retinopathy. International Journal of Molecular Sciences, 22(9), 4481.

Lee, N. G., Jeung, I. C., Heo, S. C., Song, J., Kim, W., Hwang, B., ... & Min, J. K. (2020). Ischemia‐induced Netrin‐4 promotes neovascularization through endothelial progenitor cell activation via Unc‐5 Netrin receptor B. The FASEB Journal, 34(1), 1231-1246.

Villanueva, A. A., Puvogel, S., Lois, P., Muñoz-Palma, E., Ramírez Orellana, M., Lubieniecki, F., ... & Palma, V. (2019). The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells. Cell Adhesion & Migration, 13(1), 33-40.

Crespo-Garcia, S., Reichhart, N., Wigdahl, J., Skosyrski, S., Kociok, N., Strauß, O., & Joussen, A. M. (2019). Lack of netrin-4 alters vascular remodeling in the retina. Graefe's Archive for Clinical and Experimental Ophthalmology, 257, 2179-2184.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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