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NUDT2

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified. [provided by RefSeq]

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 2

Function

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity).
Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).

Biological Process

AMP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Apoptotic processBy SimilarityISS:UniProtKB
ATP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressTAS:Reactome
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrial matrix

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Anti-NUDT2 antibodies

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Mouse Anti-NUDT2 Recombinant Antibody (4A4-3C3) (CBMAB-A6177-LY)

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Target: NUDT2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A4-3C3

Application*: WB, E

Human Recombinant NUDT2 protein, His Tag (V2LY-0526-LY5861)

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Target: NUDT2

Expressed Host: E. coli

Sequence: Amino Acid: 1-147

Tag: His Tag

Mouse Anti-NUDT2 Recombinant Antibody (CBWJN-0406) (CBMAB-N3893-WJ)

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Target: NUDT2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0406

Application*: E, WB

Rabbit Anti-NUDT2 Recombinant Antibody (CBWJN-1601) (CBMAB-N3892-WJ)

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Target: NUDT2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-1601

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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