NUDT2

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified. [provided by RefSeq]

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 2

Function

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity).
Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).

Biological Process

AMP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Apoptotic processBy SimilarityISS:UniProtKB
ATP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressTAS:Reactome
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrial matrix