Mouse Anti-NUDT2 Recombinant Antibody (4A4-3C3) (CBMAB-A6177-LY)

The product is antibody recognizes NUDT2. The antibody 4A4-3C3 immunoassay techniques such as: WB, ELISA.
See all NUDT2 antibodies

Published Data

Fig. 1 Western blot

Fig. 2 Expression of NUDT2 in the breast carcinoma.

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4A4-3C3

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

NUDT2 (AAH04926, 1 a.a. ~ 147 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 2

Introduction

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified. [provided by RefSeq]

Entrez Gene ID

318

UniProt ID

P50583

Alternative Names

APAH1; MGC10404

Function

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity).
Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).

Biological Process

AMP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Apoptotic processBy SimilarityISS:UniProtKB
ATP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressTAS:Reactome
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrial matrix

References

Bi, B., Chen, X., Huang, S., Peng, M., Gu, W., Zhu, H., & Ming, Y. (2024). The first case of intellectual disability caused by novel compound heterozygosity for NUDT2 variants. BMC pediatrics, 24(1), 60.

Hidmi, S., Nechushtan, H., Razin, E., & Tshori, S. (2023). Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma. International Journal of Molecular Sciences, 24(13), 10513.

Husain, R. A., Jiao, X., Hennings, J. C., Giesecke, J., Palsule, G., Beck-Wödl, S., ... & Rubio, I. (2023). Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease. Brain, awad434.

Razin, E., Abu-rahmah, R., Nechushtan, H., Meirovitz, A., & Peretz, T. (2023). The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer.

Laudenbach, B. T., Krey, K., Emslander, Q., Andersen, L. L., Reim, A., Scaturro, P., ... & Pichlmair, A. (2021). NUDT2 initiates viral RNA degradation by removal of 5′-phosphates. Nature Communications, 12(1), 6918.

Mishra, S., Khosa, S., Lee, H., Singer, R., Diaz, F., Freundlich, R., ... & Fogel, B. L. (2020). NUDT2 Associated Syndrome with Developmental Delay and Peripheral Neuropathy.(1629).

Diaz, F., Khosa, S., Niyazov, D., Lee, H., Person, R., Morrow, M. M., ... & Mishra, S. K. (2020). Novel NUDT2 variant causes intellectual disability and polyneuropathy. Annals of Clinical and Translational Neurology, 7(11), 2320-2325.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-NUDT2 Recombinant Antibody (CBWJN-0406)

Rabbit Anti-NUDT2 Recombinant Antibody (CBWJN-1601)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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