NUDT3

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 3

Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10419486, PubMed:12370170, PubMed:9822604, PubMed:10585413).
InsP6 (inositol hexakisphosphate) is not a substrate (PubMed:9822604).
Acts as a negative regulator of the ERK1/2 pathway (By similarity).
Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (PubMed:12370170).
The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (PubMed:12370170).
Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170).
Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility (PubMed:26932476).

Biological Process

Adenosine 5'-(hexahydrogen pentaphosphate) catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Diadenosine hexaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine pentaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine polyphosphate catabolic processManual Assertion Based On ExperimentTAS:ProtInc
Diphosphoinositol polyphosphate catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Diphosphoinositol polyphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
RNA decappingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm