NUP58

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Nucleoporin 58

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

mRNA transportIEA:UniProtKB-KW
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Protein transportIEA:UniProtKB-KW
Regulation of protein import into nucleusIEA:Ensembl

Nucleus, nuclear pore complex
Nucleus membrane
Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.

O-glycosylated.