NUPR1

Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Nuclear Protein 1, Transcriptional Regulator

Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898).
Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848).
Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310).
Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804).
Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828).
Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity).
Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity).
Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074).
Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591).
Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740).
Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804).
Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity).
Also required for LHB expression and ovarian maturation (By similarity).
Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).

Acute inflammatory responseIEA:Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEA:Ensembl
Male gonad developmentIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cardiac muscle cell apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of epithelial cell apoptotic processISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Negative regulation of fibroblast proliferationIEA:Ensembl
Negative regulation of glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of programmed necrotic cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of type B pancreatic cell proliferationISS:UniProtKB
Positive regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuroinflammatory responseISS:UniProtKB
Positive regulation of neuron apoptotic processISS:UniProtKB
Positive regulation of oxidative phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein modification processIEA:Ensembl
Protein acetylationIEA:Ensembl
Protein-containing complex assemblyIEA:Ensembl
Regulation of autophagyISS:UniProtKB
Regulation of female gonad developmentIEA:Ensembl
Regulation of response to endoplasmic reticulum stressManual Assertion Based On ExperimentIMP:UniProtKB
Response to toxic substanceIEA:Ensembl
Skeletal muscle cell differentiationIEA:Ensembl

Nucleus
Cytoplasm
Cytoplasm, perinuclear region

Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity.
Acetylated by EP300 in vitro.