OAT

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.
Full Name
ornithine aminotransferase
Function
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Biological Process
Arginine catabolic process to glutamateManual Assertion Based On ExperimentIBA:GO_Central
Arginine catabolic process to proline via ornithineManual Assertion Based On ExperimentIBA:GO_Central
L-proline biosynthetic processIEA:UniProtKB-UniPathway
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA):
A disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.
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Anti-OAT antibodies

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Mouse Anti-OAT Recombinant Antibody (CBFYH-2685) (CBMAB-H3742-FY)

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Target: OAT
Host: Mouse
Specificity: Human
Clone: CBFYH-2685
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-OAT Recombinant Antibody (CBXO-0249) (CBMAB-O0214-CQ)

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Target: OAT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0249
Application*: IH
Datasheet SDS

Mouse Anti-OAT (AA 33-439) Recombinant Antibody (AT23A2) (CBMAB-O0213-CQ)

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Target: OAT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: AT23A2
Application*: E, F, IF, WB
Datasheet SDS

Mouse Anti-OAT (AA 33-439) Recombinant Antibody (CBXO-0201) (CBMAB-O0212-CQ)

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Target: OAT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0201
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-OAT (AA 33-439) Recombinant Antibody (CBXO-0558) (CBMAB-O0029-CQ)

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Target: OAT
Host: Rabbit
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0558
Application*: WB, E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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