Mouse Oat ELISA Kit (V2LY-0626-LY2815)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.56 mU/mL
Detection Range
1-400 mU/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
48.4 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
ornithine aminotransferase
Function
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Biological Process
Arginine catabolic process to glutamateManual Assertion Based On ExperimentIBA:GO_Central
Arginine catabolic process to proline via ornithineManual Assertion Based On ExperimentIBA:GO_Central
L-proline biosynthetic processIEA:UniProtKB-UniPathway
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA):
A disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.

Lee, M. S., Dennis, C., Naqvi, I., Dailey, L., Lorzadeh, A., Ye, G., ... & Kalaany, N. Y. (2023). Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature, 616(7956), 339-347.

Boffa, I., Polishchuk, E., De Stefano, L., Dell'Aquila, F., Nusco, E., Marrocco, E., ... & Brunetti‐Pierri, N. (2023). Liver‐directed gene therapy for ornithine aminotransferase deficiency. EMBO Molecular Medicine, 15(4), e17033.

Shen, S., Butrin, A., Beaupre, B. A., Ferreira, G. M., Doubleday, P. F., Grass, D. H., ... & Silverman, R. B. (2023). Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S, 4 S)-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules, 28(3), 1133.

Silverman, R. B. (2021). Inactivators of ornithine aminotransferase for the treatment of hepatocellular carcinoma. ACS Medicinal Chemistry Letters, 13(1), 38-49.

Montioli, R., Bellezza, I., Desbats, M. A., Voltattorni, C. B., Salviati, L., & Cellini, B. (2021). Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1869(1), 140555.

Anwar, A., Wang, K., Wang, J., Shi, L., Du, L., & Ye, X. (2021). Expression of Arabidopsis Ornithine Aminotransferase (AtOAT) encoded gene enhances multiple abiotic stress tolerances in wheat. Plant cell reports, 40(7), 1155-1170.

Moschitto, M. J., Doubleday, P. F., Catlin, D. S., Kelleher, N. L., Liu, D., & Silverman, R. B. (2019). Mechanism of Inactivation of Ornithine Aminotransferase by (1 S, 3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl) cyclopentane-1-carboxylic Acid. Journal of the American Chemical Society, 141(27), 10711-10721.

Liu, Y., Wu, L., Li, K., Liu, F., Wang, L., Zhang, D., ... & Yang, S. (2019). Ornithine aminotransferase promoted the proliferation and metastasis of non‐small cell lung cancer via upregulation of miR‐21. Journal of Cellular Physiology, 234(8), 12828-12838.

Montioli, R., Paiardini, A., Giardina, G., Zanzoni, S., Cutruzzola, F., Cellini, B., & Borri Voltattorni, C. (2019). R180T variant of δ‐ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X‐ray and NMR studies provide insight into its catalytic features. The FEBS journal, 286(14), 2787-2798.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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