Mouse Anti-OAT Recombinant Antibody (CBXO-0249) (CBMAB-O0214-CQ)

Name: Mouse Anti-OAT Recombinant Antibody (CBXO-0249)
SKU: CBMAB-O0214-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0249

Application

IHC

Immunogen

Recombinant protein corresponding to human OAT

Specificity

Human

Antibody Isotype

IgG1, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

0.09% Sodium Azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ornithine aminotransferase

Introduction

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.

Entrez Gene ID

4942

UniProt ID

P04181

Alternative Names

Ornithine Aminotransferase; Ornithine Delta-Aminotransferase; Gyrate Atrophy; EC 2.6.1.13; Ornithine Aminotransferase, Mitochondrial; Ornithine Aminotransferase Precursor; Ornithine--Oxo-Acid Aminotransferase; Ornithine-Oxo-Acid Aminotransferase

Function

Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.

Biological Process

Arginine catabolic process to glutamateManual Assertion Based On ExperimentIBA:GO_Central
Arginine catabolic process to proline via ornithineManual Assertion Based On ExperimentIBA:GO_Central
L-proline biosynthetic processIEA:UniProtKB-UniPathway
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrion matrix

Involvement in disease

Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA):
A disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.

Lee, M. S., Dennis, C., Naqvi, I., Dailey, L., Lorzadeh, A., Ye, G., ... & Kalaany, N. Y. (2023). Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature, 616(7956), 339-347.

Boffa, I., Polishchuk, E., De Stefano, L., Dell'Aquila, F., Nusco, E., Marrocco, E., ... & Brunetti‐Pierri, N. (2023). Liver‐directed gene therapy for ornithine aminotransferase deficiency. EMBO Molecular Medicine, 15(4), e17033.

Shen, S., Butrin, A., Beaupre, B. A., Ferreira, G. M., Doubleday, P. F., Grass, D. H., ... & Silverman, R. B. (2023). Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S, 4 S)-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules, 28(3), 1133.

Silverman, R. B. (2021). Inactivators of ornithine aminotransferase for the treatment of hepatocellular carcinoma. ACS Medicinal Chemistry Letters, 13(1), 38-49.

Montioli, R., Bellezza, I., Desbats, M. A., Voltattorni, C. B., Salviati, L., & Cellini, B. (2021). Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1869(1), 140555.

Anwar, A., Wang, K., Wang, J., Shi, L., Du, L., & Ye, X. (2021). Expression of Arabidopsis Ornithine Aminotransferase (AtOAT) encoded gene enhances multiple abiotic stress tolerances in wheat. Plant cell reports, 40(7), 1155-1170.

Moschitto, M. J., Doubleday, P. F., Catlin, D. S., Kelleher, N. L., Liu, D., & Silverman, R. B. (2019). Mechanism of Inactivation of Ornithine Aminotransferase by (1 S, 3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl) cyclopentane-1-carboxylic Acid. Journal of the American Chemical Society, 141(27), 10711-10721.

Liu, Y., Wu, L., Li, K., Liu, F., Wang, L., Zhang, D., ... & Yang, S. (2019). Ornithine aminotransferase promoted the proliferation and metastasis of non‐small cell lung cancer via upregulation of miR‐21. Journal of Cellular Physiology, 234(8), 12828-12838.

Montioli, R., Paiardini, A., Giardina, G., Zanzoni, S., Cutruzzola, F., Cellini, B., & Borri Voltattorni, C. (2019). R180T variant of δ‐ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X‐ray and NMR studies provide insight into its catalytic features. The FEBS journal, 286(14), 2787-2798.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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