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Rabbit Anti-OAT (AA 33-439) Recombinant Antibody (CBXO-0558) (CBMAB-O0029-CQ)

This product is a rabbit antibody that recognizes OAT (AA 33-439). The antibody CBXO-0558 can be used for immunoassay techniques such as: WB, ELISA, IF.
See all OAT antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXO-0558
Antibody Isotype
IgG1, Κ
Application
WB, ELISA, IF

Basic Information

Immunogen
Recombinant human OAT (33-439aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 33-439

Target

Full Name
ornithine aminotransferase
Introduction
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.
Entrez Gene ID
4942
UniProt ID
P04181
Alternative Names
Ornithine Aminotransferase; Ornithine Delta-Aminotransferase; Gyrate Atrophy; EC 2.6.1.13; Ornithine Aminotransferase, Mitochondrial; Ornithine Aminotransferase Precursor; Ornithine--Oxo-Acid Aminotransferase; Ornithine-Oxo-Acid Aminotransferase
Function
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Biological Process
Arginine catabolic process to glutamateManual Assertion Based On ExperimentIBA:GO_Central
Arginine catabolic process to proline via ornithineManual Assertion Based On ExperimentIBA:GO_Central
L-proline biosynthetic processIEA:UniProtKB-UniPathway
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA):
A disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.

Lee, M. S., Dennis, C., Naqvi, I., Dailey, L., Lorzadeh, A., Ye, G., ... & Kalaany, N. Y. (2023). Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature, 616(7956), 339-347.

Boffa, I., Polishchuk, E., De Stefano, L., Dell'Aquila, F., Nusco, E., Marrocco, E., ... & Brunetti‐Pierri, N. (2023). Liver‐directed gene therapy for ornithine aminotransferase deficiency. EMBO Molecular Medicine, 15(4), e17033.

Shen, S., Butrin, A., Beaupre, B. A., Ferreira, G. M., Doubleday, P. F., Grass, D. H., ... & Silverman, R. B. (2023). Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S, 4 S)-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules, 28(3), 1133.

Silverman, R. B. (2021). Inactivators of ornithine aminotransferase for the treatment of hepatocellular carcinoma. ACS Medicinal Chemistry Letters, 13(1), 38-49.

Montioli, R., Bellezza, I., Desbats, M. A., Voltattorni, C. B., Salviati, L., & Cellini, B. (2021). Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1869(1), 140555.

Anwar, A., Wang, K., Wang, J., Shi, L., Du, L., & Ye, X. (2021). Expression of Arabidopsis Ornithine Aminotransferase (AtOAT) encoded gene enhances multiple abiotic stress tolerances in wheat. Plant cell reports, 40(7), 1155-1170.

Moschitto, M. J., Doubleday, P. F., Catlin, D. S., Kelleher, N. L., Liu, D., & Silverman, R. B. (2019). Mechanism of Inactivation of Ornithine Aminotransferase by (1 S, 3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl) cyclopentane-1-carboxylic Acid. Journal of the American Chemical Society, 141(27), 10711-10721.

Liu, Y., Wu, L., Li, K., Liu, F., Wang, L., Zhang, D., ... & Yang, S. (2019). Ornithine aminotransferase promoted the proliferation and metastasis of non‐small cell lung cancer via upregulation of miR‐21. Journal of Cellular Physiology, 234(8), 12828-12838.

Montioli, R., Paiardini, A., Giardina, G., Zanzoni, S., Cutruzzola, F., Cellini, B., & Borri Voltattorni, C. (2019). R180T variant of δ‐ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X‐ray and NMR studies provide insight into its catalytic features. The FEBS journal, 286(14), 2787-2798.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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