OPRK1

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Opioid Receptor Kappa 1

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Adenylate cyclase-inhibiting opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Behavioral response to cocaineIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Conditioned place preferenceIEA:Ensembl
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorISS:UniProtKB
Maternal behaviorIEA:Ensembl
Negative regulation of luteinizing hormone secretionIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Positive regulation of dopamine secretionIEA:Ensembl
Positive regulation of eating behaviorIEA:Ensembl
Positive regulation of locomotionIEA:Ensembl
Positive regulation of p38MAPK cascadeIEA:Ensembl
Positive regulation of potassium ion transmembrane transportIEA:Ensembl
Regulation of saliva secretionISS:UniProtKB
Regulation of sensory perception of painIEA:Ensembl
Response to acrylamideIEA:Ensembl
Response to estrogenIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to insulinIEA:Ensembl
Response to morphineIEA:Ensembl
Response to radiationIEA:Ensembl
Sensory perceptionManual Assertion Based On ExperimentTAS:ProtInc
Sensory perception of painISS:UniProtKB
Sensory perception of temperature stimulusIEA:Ensembl

Cell membrane

Extracellular: 1-57
Helical: 58-85
Cytoplasmic: 86-95
Helical: 96-119
Extracellular: 120-132
Helical: 133-154
Cytoplasmic: 155-173
Helical: 174-196
Extracellular: 197-222
Helical: 223-247
Cytoplasmic: 248-274
Helical: 275-296
Extracellular: 297-311
Helical: 312-333
Cytoplasmic: 334-380