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OXA1L

This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]
Full Name
OXA1L, Mitochondrial Inner Membrane Protein
Function
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.
Biological Process
Aerobic respirationManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial cytochrome c oxidase assemblyManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrial proton-transporting ATP synthase complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial respiratory chain complex I assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ATP-dependent activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidoreductase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein insertion into membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein insertion into mitochondrial inner membrane from matrixManual Assertion Based On ExperimentIBA:GO_Central
Protein tetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial intermembrane: 1-113
Helical: 114-134
Mitochondrial matrix: 135-139
Helical: 140-160
Mitochondrial intermembrane: 161-212
Helical: 213-233
Mitochondrial matrix: 234-260
Helical: 261-281
Mitochondrial intermembrane: 282-299
Helical: 300-320
Mitochondrial matrix: 321-435
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Anti-OXA1L antibodies

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Mouse Anti-OXA1L Recombinant Antibody (CF323) (CBMAB-FT192LY)

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Target: OXA1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF323
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-OXA1L Recombinant Antibody (CBFYH-3626) (CBMAB-H4184-FY)

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Target: OXA1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3626
Application*: E
Datasheet SDS

Mouse Anti-OXA1L Recombinant Antibody (CBFYH-2695) (CBMAB-H3753-FY)

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Target: OXA1L
Host: Mouse
Specificity: Human
Clone: CBFYH-2695
Application*: E, LF
Datasheet SDS

Mouse Anti-OXA1L Recombinant Antibody (CBFYH-2694) (CBMAB-H3752-FY)

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Target: OXA1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2694
Application*: E
Datasheet SDS

Mouse Anti-OXA1L Recombinant Antibody (CBFYH-2693) (CBMAB-H3751-FY)

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Target: OXA1L
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2693
Application*: E, WB
Datasheet SDS

Mouse Anti-OXA1L Recombinant Antibody (CBFYH-2692) (CBMAB-H3750-FY)

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Target: OXA1L
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2692
Application*: E, WB
Datasheet SDS

Rat Anti-OXA1L Monoclonal Antibody (CBFYH-3298) (CBMAB-H0177-FY)

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Target: OXA1L
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3298
Application*: E
Datasheet SDS

Mouse Anti-OXA1L Recombinant Antibody (CBXO-0409) (CBMAB-O0794-CQ)

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Target: OXA1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0409
Application*: E, WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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