Mouse Anti-OXA1L Recombinant Antibody (CF323) (CBMAB-FT192LY)

Name: Mouse Anti-OXA1L Recombinant Antibody (CF323)
SKU: CBMAB-FT192LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CF323

Application

ELISA, WB, IHC

Immunogen

oxidase (cytochrome c) assembly 1-like

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

OXA1L, Mitochondrial Inner Membrane Protein

Introduction

This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]

Entrez Gene ID

5018

UniProt ID

Q15070

Function

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.

Biological Process

Aerobic respirationManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial cytochrome c oxidase assemblyManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrial proton-transporting ATP synthase complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial respiratory chain complex I assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ATP-dependent activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidoreductase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein insertion into membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein insertion into mitochondrial inner membrane from matrixManual Assertion Based On ExperimentIBA:GO_Central
Protein tetramerizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion inner membrane

Topology

Mitochondrial intermembrane: 1-113
Helical: 114-134
Mitochondrial matrix: 135-139
Helical: 140-160
Mitochondrial intermembrane: 161-212
Helical: 213-233
Mitochondrial matrix: 234-260
Helical: 261-281
Mitochondrial intermembrane: 282-299
Helical: 300-320
Mitochondrial matrix: 321-435

Poerschke, S., Oeljeklaus, S., Cruz-Zaragoza, L. D., Schendzielorz, A., Dahal, D., Hillen, H. S., ... & Rehling, P. (2024). Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Molecular Cell, 84(2), 345-358.

Yang, H., & Desai, N. (2021). Purification of mitochondrial ribosomes with the translocase Oxa1L from HEK cells. Bio-protocol, 11(15), e4110-e4110.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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