PACSIN1

PACSIN1 has biased expression in brain (RPKM 42.1) and lymph node (RPKM 1.5).

Full Name

Protein Kinase C And Casein Kinase Substrate In Neurons 1

Function

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity).
Binds to membranes via its F-BAR domain and mediates membrane tubulation.

Biological Process

Actin filament organizationIEA:InterPro
Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of endocytosisIEA:Ensembl
Neuron projection morphogenesisISS:UniProtKB
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of dendrite developmentISS:BHF-UCL
Protein localization to membraneISS:UniProtKB
Protein localization to plasma membraneISS:BHF-UCL
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Synaptic vesicle endocytosisISS:UniProtKB

Cellular Location

Cytoplasm
Cell projection
Cell junction, synapse, synaptosome
Cell projection, ruffle membrane
Membrane
Cytoplasmic vesicle membrane
Cell junction, synapse
Cytoplasm, cytosol
Cell membrane
Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity).
Associates with membranes via its F-BAR domain.

PTM

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).