PAIP1

PAIP1 interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Full Name

Poly(A) Binding Protein Interacting Protein 1

Function

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
(Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.

Biological Process

CRD-mediated mRNA stabilizationManual Assertion Based On ExperimentIDA:ComplexPortal
mRNA stabilizationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of cytoplasmic translationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of translational initiationManual Assertion Based On ExperimentIBA:GO_Central
Translational initiationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm