Mouse Anti-PAIP1 Recombinant Antibody (2D11) (CBMAB-P0683-YC)

Name: Mouse Anti-PAIP1 Recombinant Antibody (2D11)
SKU: CBMAB-P0683-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D11

Application

ELISA, WB

Immunogen

PAIP1 (NP_001002, 76-185 aa) partial recombinant protein with GST tag. Immunogen sequence: YPTLSEYVQD FLNHLTEQPG SFETEIEQFA ETLNGCVTTD DALQELVELI YQQATSIPNF SYMGARLCNY LSHHLTISPQ SGNFRQLLLQ RCRTEYEVKD QAAKGDEVTR

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Poly(A) Binding Protein Interacting Protein 1

Introduction

PAIP1 interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Entrez Gene ID

10605

UniProt ID

Q9H074

Alternative Names

Poly(A) Binding Protein Interacting Protein 1; PABP-Interacting Protein 1; PAIP-1; Polyadenylate-Binding Protein-Interacting Protein 1; Poly(A)-Binding Protein-Interacting Protein 1; PABC1-Interacting Protein 1;

Function

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
(Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.

Biological Process

CRD-mediated mRNA stabilizationManual Assertion Based On ExperimentIDA:ComplexPortal
mRNA stabilizationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of cytoplasmic translationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of translational initiationManual Assertion Based On ExperimentIBA:GO_Central
Translational initiationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm

Yin, G., Jia, S., Zhang, Y., Xian, Y., Guo, Y., & Liu, Q. (2024). YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1. Archives of Biochemistry and Biophysics, 109921.

Xue, M., Cong, F., Zheng, W., Xu, R., Liu, X., Bao, H., ... & Ge, W. (2023). Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1. Cell Death Discovery, 9(1), 288.

Bi, J., Ma, H., Liu, Y., Huang, A., Xiao, Y., Shu, W. J., ... & Zhang, T. (2021). Upregulation of PAIP1 promotes the gallbladder tumorigenesis through regulating PLK1 level. Annals of Translational Medicine, 9(12).

Lei, J., Ma‐Lauer, Y., Han, Y., Thoms, M., Buschauer, R., Jores, J., ... & von Brunn, A. (2021). The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation. The EMBO journal, 40(11), e102277.

Kim, H., Jung, W., Kim, A., Kim, H. K., & Kim, B. H. (2020). High Paip1 expression as a potential prognostic marker in hepatocellular carcinoma. In Vivo, 34(5), 2491-2497.

Guan, H., Li, N., Wang, X., Shan, X., Li, Z., & Lin, Z. (2019). Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Experimental cell research, 376(2), 198-209.

Ivanov, A., Shuvalova, E., Egorova, T., Shuvalov, A., Sokolova, E., Bizyaev, N., ... & Alkalaeva, E. (2019). Polyadenylate-binding protein–interacting proteins PAIP1 and PAIP2 affect translation termination. Journal of Biological Chemistry, 294(21), 8630-8639.

Li, N., Piao, J., Wang, X., Kim, K. Y., Bae, J. Y., Ren, X., & Lin, Z. (2019). Paip1 indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis. Cancer Research and Treatment: Official Journal of Korean Cancer Association, 51(4), 1653.

Wang, Q., Han, A., Chen, L., Sun, J., Lin, Z., Zhang, X., & Ren, X. (2019). Paip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients. OncoTargets and therapy, 6565-6576.

Wang, Y., Piao, J., Wang, Q., Cui, X., Meng, Z., Jin, T., & Lin, Z. (2019). Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma. Human Pathology, 86, 233-242.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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