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Mouse Anti-PAIP1 Recombinant Antibody (2D11) (CBMAB-P0683-YC)

Provided herein is a Mouse monoclonal antibody against Human Poly(A) Binding Protein Interacting Protein 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PAIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D11
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Immunogen
PAIP1 (NP_001002, 76-185 aa) partial recombinant protein with GST tag. Immunogen sequence: YPTLSEYVQD FLNHLTEQPG SFETEIEQFA ETLNGCVTTD DALQELVELI YQQATSIPNF SYMGARLCNY LSHHLTISPQ SGNFRQLLLQ RCRTEYEVKD QAAKGDEVTR
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Poly(A) Binding Protein Interacting Protein 1
Introduction
PAIP1 interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Entrez Gene ID
10605
UniProt ID
Q9H074
Alternative Names
Poly(A) Binding Protein Interacting Protein 1; PABP-Interacting Protein 1; PAIP-1; Polyadenylate-Binding Protein-Interacting Protein 1; Poly(A)-Binding Protein-Interacting Protein 1; PABC1-Interacting Protein 1;
Function
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
(Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
Biological Process
CRD-mediated mRNA stabilizationManual Assertion Based On ExperimentIDA:ComplexPortal
mRNA stabilizationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of cytoplasmic translationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of translational initiationManual Assertion Based On ExperimentIBA:GO_Central
Translational initiationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm

Yin, G., Jia, S., Zhang, Y., Xian, Y., Guo, Y., & Liu, Q. (2024). YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1. Archives of Biochemistry and Biophysics, 109921.

Xue, M., Cong, F., Zheng, W., Xu, R., Liu, X., Bao, H., ... & Ge, W. (2023). Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1. Cell Death Discovery, 9(1), 288.

Bi, J., Ma, H., Liu, Y., Huang, A., Xiao, Y., Shu, W. J., ... & Zhang, T. (2021). Upregulation of PAIP1 promotes the gallbladder tumorigenesis through regulating PLK1 level. Annals of Translational Medicine, 9(12).

Lei, J., Ma‐Lauer, Y., Han, Y., Thoms, M., Buschauer, R., Jores, J., ... & von Brunn, A. (2021). The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation. The EMBO journal, 40(11), e102277.

Kim, H., Jung, W., Kim, A., Kim, H. K., & Kim, B. H. (2020). High Paip1 expression as a potential prognostic marker in hepatocellular carcinoma. In Vivo, 34(5), 2491-2497.

Guan, H., Li, N., Wang, X., Shan, X., Li, Z., & Lin, Z. (2019). Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Experimental cell research, 376(2), 198-209.

Ivanov, A., Shuvalova, E., Egorova, T., Shuvalov, A., Sokolova, E., Bizyaev, N., ... & Alkalaeva, E. (2019). Polyadenylate-binding protein–interacting proteins PAIP1 and PAIP2 affect translation termination. Journal of Biological Chemistry, 294(21), 8630-8639.

Li, N., Piao, J., Wang, X., Kim, K. Y., Bae, J. Y., Ren, X., & Lin, Z. (2019). Paip1 indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis. Cancer Research and Treatment: Official Journal of Korean Cancer Association, 51(4), 1653.

Wang, Q., Han, A., Chen, L., Sun, J., Lin, Z., Zhang, X., & Ren, X. (2019). Paip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients. OncoTargets and therapy, 6565-6576.

Wang, Y., Piao, J., Wang, Q., Cui, X., Meng, Z., Jin, T., & Lin, Z. (2019). Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma. Human Pathology, 86, 233-242.

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For research use only. Not intended for any clinical use.

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