PAIP2

PAIP2 has ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues.

Full Name

Poly(A) Binding Protein Interacting Protein 2

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Biological Process

MemoryIEA:Ensembl
Negative regulation of translationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of long-term synaptic potentiationIEA:Ensembl
SpermatogenesisIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Ubiquitinated, leading to its degradation by the proteasome.

Anti-PAIP2 antibodies

Mouse Anti-PAIP2 Recombinant Antibody (1C12) (CBMAB-P0687-YC)

Datasheet

SDS

Target: PAIP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1C12

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)